Open AccessFractional CO2 laser: a new therapeutic system forphotobiomodulation of skin remodeling and cytokineproduction in the course of tissue reparation
Author(s) -
Francesca Prignano,
Piero Campolmi,
P Bonnan,
Federica Ricceri,
Giovanni Cannarozzo,
Michela Troiano,
Torello Lotti
Publication year - 2011
Publication title -
vestnik dermatologii i venerologii
Language(s) - English
Resource type - Journals
eISSN - 2313-6294
pISSN - 0042-4609
DOI - 10.25208/vdv1046
Subject(s) - medicine , immunohistochemistry , hyperpigmentation , dermatology , wrinkle , laser , laser treatment , irradiation , skin hyperpigmentation , cytokine , pathology , gerontology , physics , nuclear physics , optics
Eighteen female patients with the signs of photoageing underwent skin rejuvenation using a fractional CO2 laser(SmartXide DOT, DEKA M.E.L.A., Florence, Italy) with varying energy density (2.07, 2.77 and 4.15 J/cm2). Clinical efficacyof the said laser irradiation parameters was assessed in all of the subjects, and the skin cytokine profile was studiedby using the immunohistochemistry technique based on skin tissue samples taken prior to the treatment, right afterthe treatment and in 3 and 30 days. There were significant improvements in the wrinkle and skin texture condition, andhyperpigmentation was reduced as a result of the treatment, which proves the efficacy of using the fractional CO2 laserfor the skin photorejuvenation. The technique ensures good clinical results and is distinguished by a short rehabilitationperiod and excellent safety profile. In the course of the immunohistochemistry, a relation between the skin cytokineproduction, reepithelization and laser irradiation density was established.