Open AccessEpidermolysis bullosa acquisita
Author(s) -
В. В. Чикин,
В. В. Чикин,
L F ZNAMENSKAYA,
Л Ф Знаменская,
М. А. Нефедова,
М. А. Нефедова,
В. А. Чариков,
В. А. Чариков
Publication year - 2015
Publication title -
vestnik dermatologii i venerologii
Language(s) - English
Resource type - Journals
eISSN - 2313-6294
pISSN - 0042-4609
DOI - 10.25208/0042-4609-2015-91-3-109-118
Subject(s) - epidermolysis bullosa acquisita , medicine , dermatology , epidermolysis bullosa , autoantibody , autoimmune disease , pathology , disease , immunology , antibody
The article describes present-day information on the pathogenesis, clinical picture, treatment and differential diagnostics of epidermolysis bullosa acquisita, an autoimmune skin disease caused by the production of anti-Type VII collagen autoantibodies and manifested mainly by subepidermal blisters and erosions. The authors present the results of a case study of a rare form of epidermolysis bullosa - epidermolysis bullosa acquisita in a male patient aged 53. A combined therapy with peroral prednisolone and subcutaneous injections of methotrexate had a positive effect in the form of epithelialization of most of the erosions.