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Optical coherence tomography and polarimetry of superficial skin biopsies
Author(s) -
Sergei R. Utz,
С. Р. Утц,
Dmitry A. Zimnyakov,
Д. А. Зимняков,
Е. М. Галкина,
Е. М. Галкина,
Е. М. Решетникова,
Е. М. Решетникова
Publication year - 2015
Publication title -
vestnik dermatologii i venerologii
Language(s) - English
Resource type - Journals
eISSN - 2313-6294
pISSN - 0042-4609
DOI - 10.25208/0042-4609-2015-91-1-85-91
Subject(s) - optical coherence tomography , discoid lupus erythematosus , epidermis (zoology) , itching , dermatology , polarimetry , materials science , stratum corneum , medicine , pathology , biomedical engineering , optics , anatomy , ophthalmology , lupus erythematosus , physics , antibody , immunology , scattering
The goal. Of this study was to develop and assess the efficacy of polarization probing of biotissues in vitro. The method is based on the determination of polarization parameters of scattered radiation. Materials and methods. The well-known superficial epidermis stripping method was applied using the Sulfacrylate self-sterile medical adhesive. Small portions of thin layers of the adhesive were applied to slide plates and then to different skin sites. The corneous layer in the normal condition and in case of skin diseases (psoriasis, lichen acuminatus, discoid lupus erythematosus, alopecia, itching and demodectic mange) was examined based on the optical coherence tomography (OCT) method using the 0CS1300SS device (Thorlabs Inc, USA). Results. The authors obtained pictures visualizing the structural organization of different layers of the epidermis using the superficial epidermis biopsy method in case of lichen acuminatus, hyperkeratosis, itching and other skin diseases. Conclusion. This method ensures non-invasive high-precision measurement of the structure of different layers of the epidermis, which may be useful both for research purposes and practical dermatology.

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