Open AccessParticular features of angiogenesis in lesions in patients suffering from basal cell epithelioma
Author(s) -
А. Н. Хлебникова,
Н. В. Новоселова
Publication year - 2014
Publication title -
vestnik dermatologii i venerologii
Language(s) - English
Resource type - Journals
eISSN - 2313-6294
pISSN - 0042-4609
DOI - 10.25208/0042-4609-2014-90-3-60-64
Subject(s) - cd34 , cd31 , basal cell epithelioma , angiogenesis , pathology , epithelioma , immunohistochemistry , basal (medicine) , basal cell carcinoma , basal cell , medicine , biology , carcinoma , stem cell , cancer research , genetics , insulin
Basal cell epithelioma is one of the most frequent malignant skin neoplasms. Angiogenesis plays an important part in the development of basal cell epithelioma. The article presents a review of the angiogenesis of this tumor with the help the immunohistochemistry analysis using CD31 and CD34 markers. The authors established a reliable relationship between the number of vessels expressing CD31 and those expressing CD34 in the superficial and nodular forms of the tumor as well as superficial, multi-center, nodular and infiltrative basal cell epitheliomas. A comparison of the number of vessels expressing CD31 and CD34 markers in different histological types made revealed a trend to their growth in the infiltrative type vs. superficial, multi-center and nodular ones.