ANALGESIC NEPHROPATHY. A MODERN VIEW ON THE PROBLEM

Aim . To review Russian and foreign literature on modern methods of diagnosis and treatment of patients with analgesic nephropathy. Materials and methods . Russian and foreign literature sources published in recent years on the aforementioned problem were analyzed. Results . This article presents the concept of analgesic nephropathy (AN) and discusses causes and mechanisms of its development. The pathogenic effect of non-steroidal antiinfl ammatory drugs on renal tissue is indicated. Key stages of the disease and its clinical features are determined. An algorithm of diagnosis is proposed. The importance of a patient’s detailed medical history is emphasized, including the duration, multiplicity and reasons for taking analgesics. A particular attention is paid to questions of AN therapy and its prevention. Provided timely diagnosis and analgesics withdrawal, the possibility of reverting tubulointerstitial infl ammation is shown. Conclusion . It is shown that optimal solutions with regard to AN diagnosis and its treatment are yet to be found. A timely diagnosis inhibits the development of chronic renal failure, which early detection provides for a higher treatment effi ciency and improved prognosis.