Open AccessAssociation between Vitamin D Receptor Gene Polymorphism and Susceptibility to Tuberculosis (TB): a Meta Analysis
Author(s) -
Yuanyuan Dong,
Yinmin Gu,
Mengxiang Guan,
Haibo Li,
Yunfei Zou,
Jiangen Song,
Lei Ding,
Yufeng Wen
Publication year - 2017
Publication title -
advances in disease control and prevention
Language(s) - English
Resource type - Journals
eISSN - 2519-965X
pISSN - 2519-9641
DOI - 10.25196/adcp20163
Subject(s) - meta analysis , funnel plot , publication bias , calcitriol receptor , tuberculosis , polymorphism (computer science) , medicine , gene polymorphism , gene , biology , genetics , oncology , vitamin d and neurology , genotype , pathology
Objective: The study was carried out to comprehensively evaluate association between Vitamin D receptor gene polymorphism and susceptibility to TB, using meta-analysis.
Methods: Literature on controlled case studies on association between vitamin D receptor gene polymorphism and TB were collected through online database (Pubmed, Chinese CNKI, VIP database, Wanfang database and Google search). Odd ratio (OR) of all the studies were collected depending on the result of their heterogeneity tests. Publication bias was assessed by using a funnel plot and Egger’s test.
Results: Eight papers were selected based on study criteria. Meta analysis results showed that the combined OR values (95%CI) of dominant model and recessive model were 0.51(0.40,0.65) and0.72(0.61, 0.85), They were both statistically significant (P<0.001). Significant associations were observed for Fok? polymorphisms among Chinese.
Conclusion: The results suggest that Vitamin D receptor gene polymorphism was significantly associated with TB in China. Our findings support the hypothesis that vitamin D deficiency might play a role in TB infection and development of associated risk factors.