Open AccessDesign and Optimization of Novel Vaginal Microsphere Gel of Clotrimazole
Author(s) -
Snehal Bhabad .,
Snehal Bhabad .,
Snehal Bhabad .
Publication year - 2021
Publication title -
international journal of pharmacy and pharmaceutical research
Language(s) - English
Resource type - Journals
ISSN - 2349-7203
DOI - 10.25166/ijppr.2021.v22i02.38
Subject(s) - bioadhesive , clotrimazole , factorial experiment , microsphere , chromatography , drug delivery , materials science , particle size , polymer , dosage form , chemistry , biomedical engineering , chemical engineering , nanotechnology , composite material , medicine , mathematics , antifungal , statistics , dermatology , engineering
The objective of the study was to develop and evaluatesustained release microsphere gel for the drug clotrimazoleto be administered through the vaginal route. The effect ofpolymer ethylcellulose and carbopol 934 on entrapmentefficiency and diffusion behavior were investigatedrespectively. A 32 full-factorial design was used to optimizethe formulation of Microsphere gel. Microspheres werecharacterized by SEM, FTIR, Entrapment efficiency, andparticle size. Gels were evaluated for in-vitro drug release insimulated vaginal fluid. The microsphere loaded withclotrimazole in bioadhesive carbopol gel formulation wasevaluated for various physicochemical studies and wasfound to be satisfactory. The rheological profile shows thegel formation at desired condition. It is evaluated forspreadability, drug content, In-vitro drug diffusion, stabilitystudy, and bioadhesive study. It may be concluded thatspray drying is a suitable method for microspherepreparation and microsphere gel can be used as a noveldrug delivery system to prolonge release of clotrimazole forvaginal candidiasis.