Open AccessBioactive Natural Products from Endophytic Fungus Aspergillus nidulans Associated with Nyctanthes arbor-tristis Linn.
Author(s) -
Talea Sana,
Bina Shaheen Siddiqui,
Majid Khan,
Saleem Shahzad,
Samia Sattar,
Sabira Begum
Publication year - 2021
Publication title -
records of natural produc
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 31
ISSN - 1307-6167
DOI - 10.25135/rnp.251.21.02.1986
Subject(s) - chemistry , ic50 , urease , fungus , stereochemistry , aspergillus niger , enzyme , traditional medicine , biochemistry , biology , botany , in vitro , medicine
Endophytic fungi are a substantial source of bioactive secondary metabolites. Present studies on Aspergillus nidulans―an endophytic fungus from Nyctanthes arbor-tristis Linn. afforded one new 1, 5-dihydroxy-3-methylxanthone-6-carboxylic acid methyl ester (1) and one known 5, 10-dihydro-phenazine-1-carboxylic acid (2) compound. The structures were elucidated by spectral techniques (Mass, 1D and 2D NMR), and their urease, carbonic anhydrase and prolyl endopeptidase inhibitory activities were evaluated. Compound 1 showed notable prolyl endopeptidase inhibition (IC50 = 3.13 ± 0.09 µM) and compound 2 showed significant carbonic anhydrase (IC50 =14.3 ± 1.05 µM) and urease (IC50 = 24.3 ± 1.15 µM) inhibition.