Open AccessCytotoxic Sesquiterpene Coumarins from the Roots of Heptaptera cilicica
Author(s) -
Fâtma Tosun,
Erdi Can Aytar,
John A. Beutler,
Jennifer A. Wilson,
Mahmut Miski
Publication year - 2021
Publication title -
records of natural produc
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 31
ISSN - 1307-6167
DOI - 10.25135/rnp.242.21.02.1990
Subject(s) - dichloromethane , coumarin , sesquiterpene , cytotoxic t cell , chemistry , stereochemistry , traditional medicine , two dimensional nuclear magnetic resonance spectroscopy , organic chemistry , biochemistry , in vitro , medicine , solvent
Preliminary 2-day cancer cell screening assays indicated that the dichloromethane extract of the roots of Heptaptera cilicica showed relatively strong cytotoxic activity. Eleven sesquiterpene coumarin ethers with potent and selective cytotoxic activities were isolated from the dichloromethane extract of the roots of H. cilicica. Furthermore, revised spectroscopic data for 14′-acetoxybadrakemone (4) and complete NMR spectroscopic assignments for colladonin (6) and colladin (7) are reported.