Open AccessIsolation and Characterization of Glycosidic Tyrosinase Inhibitors from Typhonium giganteum Rhizomes
Author(s) -
Penghua Shu,
Huiqing Zhu,
Wanrong Liu,
Lingxiang Zhang,
Junping Li,
Mengzhu Yu,
Yingying Fei,
Shujing Cai,
Ruihua Li,
Xialan Wei,
Wenhan Yi,
Fugang Xiao
Publication year - 2021
Publication title -
records of natural produc
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 31
ISSN - 1307-6167
DOI - 10.25135/rnp.230.21.02.1965
Subject(s) - glycoside , arbutin , phenylethanoid , chemistry , glucoside , lignan , tyrosinase , rhizome , glycosidic bond , pregnane , stereochemistry , biochemistry , traditional medicine , enzyme , medicine , alternative medicine , pathology
A new hydrocinnamoyl glucoside, 1-O-(4-hydroxyhydrocinnamoyl)-β-D-glucopyranose (1), together with fifteen known glycosides, including two phenylethanoid glycosides (2–3), two cinnamoyl glycosides (4–5), six phenolic glycosides (6–11), one lignan glycoside (12) and four megastigmane glycosides (13–16) were isolated from a 95% EtOH extract of the Typhonium giganteum rhizomes. The sixteen glycosides were structurally characterized by NMR, HRESIMS, enzymatic hydrolysis and comparison with literature. Upon evaluating inhibitory activities of compounds 1–16 against mushroom tyrosinase at 25 μM, compounds 10 and 11 exhibited obvious inhibitory activities, with %inhibition values of 20.94±0.59%, 23.28±1.09%, respectively, with arbutin used as the positive control (26.21±0.58%).