Open AccessCyclic Polyketides with α-Glucosidase Inhibitory Activity from Endiandra kingiana Gamble and Molecular Docking Study
Author(s) -
Mohamad Nurul Azmi,
Nur Amirah Saad,
Mohamad Hafizi Abu Bakar,
Che Omar,
Ahmad Nazif Aziz,
Habibah A. Wahab,
Sadia Siddiq,
M. Iqbal Choudhary,
Marc Litaudon,
Khalijah Awang
Publication year - 2021
Publication title -
records of natural produc
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 31
ISSN - 1307-6167
DOI - 10.25135/rnp.227.20.11.1889
Subject(s) - chemistry , phytochemical , docking (animal) , stereochemistry , ic50 , in vitro , active site , enzyme , two dimensional nuclear magnetic resonance spectroscopy , biochemistry , medicine , nursing
A phytochemical investigation of the methanolic extract of Endiandra kingiana (bark) led to the isolation of four major compounds which are kingianic acid A (1), tsangibeilin B (2), kingianin A (3) and kingianin F (4). The structures were determined by 1D- and 2D-NMR analysis in combination with HRMS experiments. The compounds were screened for their in vitro α-glucosidase inhibition activity. Among them, compounds 3-4 showed potent α-glucosidase inhibition activity with IC50 value at 11.9 ± 2.0 µM and 19.7 ± 1.5 µM, respectively. The molecular docking study found that both compounds were bound into the active site of the N-terminal of MGAM, and thus agreed with the in vitro α-glucosidase enzyme inhibition activity results.