Open AccessEudesmane Sesquiterpenoids from Salvia plebeia
Author(s) -
Li Y,
Yifang Chen
Publication year - 2021
Publication title -
records of natural produc
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 31
ISSN - 1307-6167
DOI - 10.25135/rnp.218.20.10.1856
Subject(s) - stereochemistry , chemistry , salvia , two dimensional nuclear magnetic resonance spectroscopy , botany , biology
A new eudesmane sesquiterpenoid (1), named sapleudesone, together with four known analogs (2-5) were isolated from the aerial parts of Salvia plebeia. The structure of compound 1 was established by NMR and HRESIMS data, and the absolute configuration of 1 was determined by comparing the experimental ECD spectrum with the calculated ECD spectra. The known compounds were identified to be salplebeone A (2), linderolide I (3), chlorantene D (4), and chlomultin B (5), respectively, by comparing the NMR data and specific rotations with reported data. All five compounds were tested for the inhibitory effects against NO production in LPS-activated RAW 264.7 macrophages. As a result, compound 2 exhibited weak inhibitory effects with an IC50 value of 42.3 ± 1.4 mM.