Open AccessA New Phenylpropanoid from the Roots of Solanum melongena L. and Evaluation of Anti-inflammatory Activity
Author(s) -
Yan Liu,
Xin Yin,
Yanping Sun,
Yuan Liu,
Dongxv Lu,
Yuanyuan Zhou,
Adnan Mohammed Algradi,
Juan Pan,
Wei Guan,
Bing-You Yang,
Haixue Kuang
Publication year - 2021
Publication title -
records of natural products
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 31
ISSN - 1307-6167
DOI - 10.25135/rnp.211.20.10.1837
Subject(s) - solanum , phenylpropanoid , chemistry , melongena , nitric oxide , ethanol , traditional medicine , botany , stereochemistry , biochemistry , organic chemistry , biosynthesis , enzyme , biology , medicine
Fifteen phenylpropanoids were isolated from the ethanol extract of the roots of Solanum melongena L., including a new compound, melongenapanoid A (1), together with fourteen known compounds (2-15). Their chemical structures were elucidated by 1D and 2D NMR and HR-MS data according to those values of the literatures. The fourteen known compounds (2-15) were all firstly isolated from this plant. While, the isolates were evaluated for the inhibitory activities on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW 264.7 cell line. Compounds 2, 4 and 5 showed moderate inhibition of NO production with IC50 values of 28.7, 24.4 and 32.6 μM, respectively.
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