Isolation, Characterization and Antiproliferative Activity of Secondary Metabolites from Tanacetum alyssifolium (Bornm.) Grierson | Zendy

Ekrem Köksal | Zendy; Yakup ULUTAŞ | Zendy; Samed Şimşek | Zendy; aha Bayraktar | Zendy; Ahmet Altay | Zendy; Mustafa Çatır | Zendy; İbrahim Demirtaş | Zendy; Ali Rıza Tüfekçi | Zendy; Ali Kandemir | Zendy; Cemalettin Alp | Zendy; Mohammed B. Anwer Alemdar Alemdar | Zendy; Hüseyin Akşit | Zendy

Open Access

Isolation, Characterization and Antiproliferative Activity of Secondary Metabolites from Tanacetum alyssifolium (Bornm.) Grierson

Author(s) -

Ekrem Köksal,

Yakup ULUTAŞ,

Samed Şimşek,

aha Bayraktar,

Ahmet Altay,

Mustafa Çatır,

İbrahim Demirtaş,

Ali Rıza Tüfekçi,

Ali Kandemir,

Cemalettin Alp,

Mohammed B. Anwer Alemdar Alemdar,

Hüseyin Akşit

Publication year - 2020

Publication title -

records of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.43

H-Index - 31

ISSN - 1307-6167

DOI - 10.25135/rnp.201.20.07.1702

Subject(s) - chemistry , acetophenone , luteolin , stereochemistry , glucoside , sesquiterpene , rutin , cytotoxicity , in vitro , flavonoid , biochemistry , antioxidant , medicine , alternative medicine , pathology , catalysis

Secondary metabolites of Tanacetum alyssifolium (Bornm.) Grierson (Asteraceae) were investigated for the first time. Thirteen compounds including axillarin (1), Luteolin-7-O-β-glucoside (8) and rutin (13) as flavonoids, fraxetin (7), isofraxidin (9), isofraxidin-7-O-glucoside (11) and fraxidin (12) as coumarins, tatridin A (2), altissin (3), tamirin (4) and tanachin (5) as sesquiterpene lactones and 2,4-dihydroxy-6-methoxy acetophenone (6) and picein (10) as acetophenone derivatives were isolated from the methanol extract of the species. The structures of all isolated compounds were elucidated by 1D and 2D-NMR techniques and by comparing with the literature data. In addition, in vitro cytotoxic activity of all isolated compounds was evaluated against breast cancer MCF-7 cell line by XTT assay. Sesquiterpene lactones; tatridin A (2), tamirin (4) and tanachin (5) were found to be the most cytotoxic molecules against MCF-7 cell line.

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