Open AccessIsolation, Characterization and Antiproliferative Activity of Secondary Metabolites from Tanacetum alyssifolium (Bornm.) Grierson
Author(s) -
Ekrem Köksal,
Yakup Ulutaş,
Samed Şimşek,
aha Bayraktar,
Ahmet Altay,
Mustafa Çatır,
İbrahim Demirtaş,
Ali Rıza Tüfekçi,
Ali Kandemir,
Cemalettin Alp,
Mohammed B. Anwer Alemdar Alemdar,
Hüseyin Akşit
Publication year - 2020
Publication title -
records of natural produc
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 31
ISSN - 1307-6167
DOI - 10.25135/rnp.201.20.07.1702
Subject(s) - chemistry , acetophenone , luteolin , stereochemistry , glucoside , sesquiterpene , rutin , cytotoxicity , in vitro , flavonoid , biochemistry , antioxidant , medicine , alternative medicine , pathology , catalysis
Secondary metabolites of Tanacetum alyssifolium (Bornm.) Grierson (Asteraceae) were investigated for the first time. Thirteen compounds including axillarin (1), Luteolin-7-O-β-glucoside (8) and rutin (13) as flavonoids, fraxetin (7), isofraxidin (9), isofraxidin-7-O-glucoside (11) and fraxidin (12) as coumarins, tatridin A (2), altissin (3), tamirin (4) and tanachin (5) as sesquiterpene lactones and 2,4-dihydroxy-6-methoxy acetophenone (6) and picein (10) as acetophenone derivatives were isolated from the methanol extract of the species. The structures of all isolated compounds were elucidated by 1D and 2D-NMR techniques and by comparing with the literature data. In addition, in vitro cytotoxic activity of all isolated compounds was evaluated against breast cancer MCF-7 cell line by XTT assay. Sesquiterpene lactones; tatridin A (2), tamirin (4) and tanachin (5) were found to be the most cytotoxic molecules against MCF-7 cell line.