Open AccessChemical Investigation of a Co-Culture of Aspergillus fumigatus D and Fusarium oxysporum R1
Author(s) -
Ronglu Yu,
Mingzhu Li,
Yi Wang,
Bai X,
Jianwei Chen,
XingNuo Li,
Hong Wang,
Huawei Zhang
Publication year - 2020
Publication title -
records of natural produc
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 31
ISSN - 1307-6167
DOI - 10.25135/rnp.199.20.07.1728
Subject(s) - fusarium oxysporum , aspergillus fumigatus , acetamide , chemistry , candida albicans , microbiology and biotechnology , stereochemistry , amide , fusarium , biology , biochemistry , organic chemistry , botany
Chemical investigation of a co-culture of two endophytic fungi Aspergillus fumigatus D and Fusarium oxysporum R1 from two traditional medicinal plants, Edgeworthia chrysantha Lindl. and Rumex madaio Makino, led to isolation of a new amide 1 and six known compounds, including neovasinin (2), neovasifuranone B (3), N-(2-phenylethyl)acetamide (4), α-linolenic acid (5), α-elaeostearic acid (6), palmitoleic acid (7). On the basis of extensive spectroscopic analysis including 1D and 2D NMR, HR-ESI-MS and optical rotation measurement as well as comparison of literature data, chemical structure of 1 was unambiguous elucidated as (S, E)-methyl-2-(2,4-dimethylhex-2-enamido)acetate. Bioassay results indicated that none of these compounds exhibited strong inhibitory effect on three human pathogens Escherichia coli, Staphyloccocus aureus and Candida albicans with MIC values of ≥25 μM.