Open AccessUltrasound-assisted efficient synthesis of 3-[4-(2-methoxyethyl) phenoxy] propane -1,2 -diol (Metoprolol EP impurity D)
Author(s) -
Zinal Soni,
Santosh Patil,
Santhosh Koppula,
Poonam Koppula
Publication year - 2021
Publication title -
organic communications
Language(s) - English
Resource type - Journals
ISSN - 1307-6175
DOI - 10.25135/acg.oc.98.20.10.1844
Subject(s) - impurity , propane , chemistry , metoprolol , molecule , drug , combinatorial chemistry , stereochemistry , materials science , organic chemistry , pharmacology , medicine
Safety of the drug molecule is dependent on the various impurities formed during chemical transformation which may cause drug product instability, decreased product performance, loss in potency, and/or formation of potentially genotoxic impurities. Therefore, it is essential to identify and quantify the impurities generated during the drug development stage. Herein, we describe the synthesis and characterization of Impurity D of Metoprolol, 3-[4-(2-methoxyethyl)phenoxy]propane-1,2-diol (1), reported in European Pharmacopeia. The synthesis of impurity D has been accomplished in two steps; starting from Epichlorhydrin under three different set of conditions.