Open AccessSynthesis of novel potential ROCK inhibitors and their antimigratory effects
Author(s) -
Sümeyye Turanlı,
Azize Gizem Uslu,
Ayşegül Özdemir
Publication year - 2020
Publication title -
organic communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.238
H-Index - 15
ISSN - 1307-6175
DOI - 10.25135/acg.oc.87.20.10.1846
Subject(s) - apoptosis , kinase , cancer cell , motility , cell growth , metastasis , chemistry , rho associated protein kinase , cancer , cytotoxic t cell , cancer research , pharmacology , microbiology and biotechnology , biology , biochemistry , medicine , in vitro
Rho kinase (ROCK), an enzyme belonging to the serine-threonine kinase family, is involved in the regulation of basic cellular processes such as morphology, movement, division, differentiation and apoptosis. On the other hand, excessively activated ROCK can cause to cardiovascular and neurological disorders or cancer. In recent years, overactivation of Rho kinases has been associated with increased metastasis in various tumor types and has been explored as target for the development of new anticancer drugs. We report here the design and synthesis of five urea derivatives in search of novel inhibitors of cancer cell migration. Compounds evaluated for their cytotoxic activities against breast (MCF-7) cancer cell line. After determination of the ineffective concentrations of compounds on the proliferation of MCF-7 cells, wound healing experiments were conducted to investigate the antimigratory effects of compounds. While compounds 4 and 10 had no effect on cell migration, treatment of MCF-7 cells with compounds 5, 8 and 9 resulted in significant reduction in cell motility. Taken together our results suggest that the newly synthesized compounds 5, 8 and 9 had the potential antimigratory activity through possible ROCK inhibition in cancer cells.