Open AccessIn vitro antiproliferative activity of some fluoro-substituted benzimidazole-based scaffolds
Author(s) -
Ronak Haj Ersan,
Nizami Duran
Publication year - 2021
Publication title -
bioorganic and medicinal chemistry reports
Language(s) - English
Resource type - Journals
ISSN - 2667-6028
DOI - 10.25135/acg.bmcr.25.21.05.2065
Subject(s) - benzimidazole , in vitro , mtt assay , chemistry , cell culture , pharmacology , combinatorial chemistry , stereochemistry , biochemistry , biology , organic chemistry , genetics
In the present work, a series of fluoro-substituted benzimidazole derivatives were designed and synthesized as antiproliferative agents. The antiproliferative activity of these compounds was investigated using MTT assay. Fluoro-substituted benzimidazole derivatives showed significant antiproliferative activity against all the tested cancer cell lines. All the derivatives were found to be less toxic as compared to methotrexate (positive control) in human cells, indicating selective and efficient antiproliferative activity of these benzimidazole derivatives. These findings suggest that compounds ORT14 and ORT15 among this series are most effective and have potential for detailed investigations.