Open AccessEngaging a polylactide copolymer in oral tissue regeneration: first validation of Suprathel® for guided epithelial and osseous healing
Author(s) -
Sergiu Văcăraş,
Grigore Băciuţ,
Dan Gheban,
Simion Bran,
Horațiu Alexandru Colosi,
Septimiu Toader,
Daiana Opriș,
W. Kretschmer,
Avram Manea,
Gabriel Armencea,
Mihaela Băciuţ,
Horia Opriș,
Ileana Mitre,
Mihaela Hedeșiu,
Cristian Dinu
Publication year - 2021
Publication title -
journal of medicine and life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.354
H-Index - 36
eISSN - 1844-3117
pISSN - 1844-122X
DOI - 10.25122/jml-2021-0083
Subject(s) - regeneration (biology) , oral mucosa , wound healing , biomaterial , medicine , dentistry , pathology , biomedical engineering , surgery , microbiology and biotechnology , biology
The present study investigated the capacity of Suprathel ® (a copolymer membrane, so far validated for skin regeneration) to also regenerate oral tissue - mucosa and bone, by comparing this biomaterial, in a split-mouth rabbit model, to Mucoderm ® , a xenogeneic collagen matrix certified for keratinized oral mucosa healing. The clinical reason behind this experimental animal model was to determine whether the benefits of this advanced skin regeneration product (Suprathel ® ) could be conveyed for future evaluation in clinical trials of oral tissue regeneration in humans. The outcomes of this study validated the use of Suprathel ® , a terpolymer of polylactide with trimethylene carbonate and ε-caprolactone, for stimulation of oral epithelium and alveolar bone regeneration in rabbits. Both Suprathel ® and Mucoderm ® exhibited comparable results and the null hypothesis stating a comparable regenerating effect of these two materials could not be rejected.