Open AccessAnalysis of long-term results of pathogenetic treatment of Helicobacter pylori-associated gastroduodenopathies induced by nonsteroidal anti-inflammatory drugs in patients with osteoarthritis
Author(s) -
Ludmila Mykhailivna Honcharuk,
О. І. Федів,
Svitlana Oleksandrivna Hresko,
Antonina Piddubna,
Ludmila Viktorivna Mikulets,
Илона Руснак,
Dmytro Olexandrovich Hontsariuk,
Yuliia Valeriievna Kokhaniuk
Publication year - 2021
Publication title -
journal of medicine and life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.354
H-Index - 36
eISSN - 1844-3117
pISSN - 1844-122X
DOI - 10.25122/jml-2020-0176
Subject(s) - medicine , helicobacter pylori , gastroenterology , osteoarthritis , nonsteroidal , tumor necrosis factor alpha , concomitant , rebamipide , pathology , alternative medicine
The study of the pathogenetic treatment and prevention of Helicobacter pylori (Hp)-associated gastroduodenopathies (GDP) induced by nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with osteoarthritis (OA) is one of the most serious problems in modern clinical medicine. Sixty patients with OA and concomitant Hp-associated GDP induced by NSAIDs were examined. The levels of epidermal growth factor (EDF), sAPO-1/Fas and tumor necrosis factor-α (TNF-α) were determined. Group I included 30 patients who received triple anti-Helicobacter (AHT) therapy, and group II included 30 patients who received rebamipide. Long-term effects were assessed 6 months and 1 year after treatment. All subjects showed a significant increase in TNF-α (4.7 times), EDF (2.2 times) and a decrease in sAPO-1/Fas (3.6 times) levels compared to healthy individuals. After 1 month of treatment, a significantly more significant decrease in TNF-α and an increase in sAPO-1/Fas and EDF was found in group II. In the long-term treatment, a further decrease in TNF-α and an increase in the content of sAPO-1/Fas levels were observed in all groups. However, these changes were significantly more significant in group I compared to group I. The long-term follow-up showed a declining trend of EDF in all groups. The data obtained indicate the effectiveness of rebamipide in the complex pathogenetic treatment and prevention of Hp-associated GDP induced by NSAIDs in patients with OA.