Open AccessMALT lymphoma: epidemiology, clinical diagnosis and treatment
Author(s) -
Petruța Violeta Filip,
Denisa Cuciureanu,
Laura Sorina Diaconu,
Ana Maria Vlădăreanu,
Corina Silvia Pop
Publication year - 2018
Publication title -
journal of medicine and life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.354
H-Index - 36
eISSN - 1844-3117
pISSN - 1844-122X
DOI - 10.25122/jml-2018-0035
Subject(s) - helicobacter pylori , lymphoma , marginal zone , malt lymphoma , mucosa associated lymphoid tissue , medicine , lymphatic system , epidemiology , pathology , gastric mucosa , gastrointestinal tract , gastric lymphoma , pathogenesis , stomach , gastroenterology , b cell , immunology , antibody
Primary gastric lymphoma (PGL) represents a rare pathology, which can be easily misdiagnosed because of unspecific symptoms of the digestive tract. Histologically, PGL can vary from indolent marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) to aggressive diffuse large B-cell lymphoma (DLBCL). During the years, clinical trials revealed the important role of Helicobacter pylori (H. pylori) in the pathogenesis of gastric MALT lymphoma. Infection with Helicobacter pylori is an influential promoter of gastric lymphomagenesis initiation. Long-term studies revealed that eradication therapy could regress gastric lymphomas.