Open AccessBiochemical markers of bone metabolism
Author(s) -
Leonardo Franco,
Mario Salazar
Publication year - 2017
Publication title -
revista estomatologia/revista estomatologâia/revista estomatología y salud
Language(s) - English
Resource type - Journals
eISSN - 2248-7220
pISSN - 0121-3873
DOI - 10.25100/re.v18i1.5707
Subject(s) - deoxypyridinoline , pyridinoline , bone resorption , hydroxyproline , chemistry , resorption , bone remodeling , type i collagen , alkaline phosphatase , tartrate resistant acid phosphatase , endocrinology , acid phosphatase , medicine , biochemistry , osteocalcin , biology , enzyme
The quantity and quality of bone tissue renewal are dependent on the generation of new bone (deposition) mediated by osteoblasts and the loss (resorption) mediated by osteoclasts. For each of these processes there are important markers that can be measured in serum or urine.
Resorption markers are products of metabolic degradation of bone matrix in particu-lar of the type I collagen (hydroxyproline, pyridinoline and deoxypyridinoline). In addition, the resorptive activity can also be evaluated through the tartrate resistant acid phosphatase (TRAP) and calcium-creatinine ratio in urine. Bone formation markers are collagen proteins (ALP, OCN), non collagen (ONC, OPN, BSP) or fragments of collagen synthesis (procollagen peptides).