Pharmacological modulation in orthodontic treatment

Summary: Patients undergoing orthodontic treatment canexperience significant levels of pain. As a consequence of the compression of the periodontalligament, are liberated chemical mediators of the inflammation which favor the bone remodeling,tooth movement, and do also generate discomfort for the patient. It is the duty of the orthodonticsto control pain in the patient, which reaches its top peak 24 hours after the mechanical activation,not minimizing the effects of the molecules that favor the osseous remodeling such as theprotaglandins and the interleukins. In the scientific literature it is proposed the use of NSAIDs tocontrol pain in orthodontics due to its analgesics and anti-inflammatory properties, besides thefact that they do not substantially minimize the velocity of the tooth movement. This review has thepurpose of describing the inflammatory process mediators of the orthodontic tooth movement, revisealternative pharmacological for the tooth movement and for the control of pain secondary to theactivation of the mechanics orthodontic and suggest an ideal NSAID for handling of the pain withminimum adverse effects on the tooth movement. Key words: Inflammation. Tooth movement. Orthodonticpain. Nonsteroidal anti-inflammatory drugs (NSAID).