Open AccessThe effects of levosimendan on renal functions in open-heart surgery patients with a low ejection fraction
Author(s) -
Süleyman Yazıcı,
Mehmet Karabulut,
Ayşe Baysal,
Rahmi Zeybek
Publication year - 2021
Publication title -
journal of clinical and investigative surgery
Language(s) - English
Resource type - Journals
ISSN - 2559-5555
DOI - 10.25083/2559.5555/6.2.6
Subject(s) - medicine , cardiopulmonary bypass , creatinine , levosimendan , ejection fraction , anesthesia , inotrope , perioperative , cardiology , cardiac surgery , renal function , blood urea nitrogen , heart failure
Purpose. This study investigated the effects of levosimendan on renal functions in patients with a preoperative low ejection fraction undergoing open-heart surgery and cardiopulmonary bypass (CPB). Materials and Methods. The study retrospectively evaluated 64 patients with a diagnosis of mitral valve insufficiency and left ventricular dysfunction undergoing open-heart surgery with CPB. Patients were divided depending on the preoperative blood creatinine level less (Group 1) or more than 1.2 mg/dL (Group 2). A bolus dose of levosimendan was administered through the aortic arch at the end of the CPB, preceding an infusion of levosimendan intravenously in all patients. Demographic data, preoperative and 48-hour postoperative echocardiographic studies were done. The blood urea and creatinine levels were collected preoperatively and on postoperative days 1, 3, and 10. The use of inotropic support, intra-aortic balloon pump, and complications were recorded. Results. The demographic data were similar between groups (p>0.05). Preoperative serum creatinine levels were higher in Group 1 in comparison to Group 2 (p=0.01, p 0.05). Preoperative serum creatinine levels were higher in Group 1 in comparison to Group 2 (p 0.05). Complications were similar between groups (p>0.05). Conclusions. In patients with low ejection fraction undergoing open-heart surgery, the use of levosimendan intraoperatively and 24 hours postoperatively prevents deterioration of renal functions in patients with or without preoperative disturbance in serum creatinine level.