Open AccessInvestigation of one bisphosphonate introduced on the structure and the dissolution of bioglass by using NMR and ICP-OES methods
Author(s) -
Bùi Xuân Vương
Publication year - 2018
Publication title -
tạp chí khoa học đại học quốc gia hà nội: khoa học tự nhiên và công nghệ (vnu journal of science:natural sciences and technology)
Language(s) - English
Resource type - Journals
eISSN - 2615-9317
pISSN - 2588-1140
DOI - 10.25073/2588-1140/vnunst.4826
Subject(s) - dissolution , composite number , simulated body fluid , bisphosphonate , materials science , nuclear chemistry , chemical engineering , chemistry , composite material , organic chemistry , medicine , scanning electron microscope , osteoporosis , engineering , endocrinology
Zoledronate (Z) - one type of bisphosphonate has associated with bioglass (BG) to elaborate composite material for medical applications. The mixture of glass particles in zoledronate solution was stirred, frozen and lyophilized to obtain composite material containing 0.1 wt% of zoledronate (noted composite BG-0.1Z). The NMR analysis highlighted the effects of zoledronate introduced on the structure of bioglass. The ICP-OES method was used to evaluate the dissolution of synthetic composite in a simulated body fluid (SBF). Obtained results show that the introduction of 0.1 wt% of zoledronate affecting to the dissolution and bioactivity of bioglass.