Open AccessAll trans retinoic acid inhibits the gene expression of self-renewal and Notch signaling pathway in gastric cancer cells
Author(s) -
Phu Hung Nguyen,
Thu Ha Ngo,
Thi Binh Luu
Publication year - 2018
Publication title -
tạp chí khoa học đại học quốc gia hà nội: khoa học tự nhiên và công nghệ (vnu journal of science:natural sciences and technology)
Language(s) - English
Resource type - Journals
eISSN - 2615-9317
pISSN - 2588-1140
DOI - 10.25073/2588-1140/vnunst.4787
Subject(s) - notch signaling pathway , cancer stem cell , hes1 , sox2 , biology , stem cell , hes3 signaling axis , signal transduction , cancer research , cancer cell , microbiology and biotechnology , cancer , retinoic acid , hmga2 , klf4 , gene , genetics , embryonic stem cell , microrna
All trans retinoic acid (ATRA) plays an important role in many cellular processes and is a potent promising substance for cancer therapy. The self-renewal is a prominent feature of cancer stem cells that is tightly controlled by a number of specific genes, and is also mediated by the cell signaling pathways. The Notch signal pathway has been shown to be one of the few major molecular signaling pathways of cancer stem cells, which regulates self-renewal and survival of cancer stem cells. In this study, we showed that ATRA reduced the expression of important genes involved in self-renewal of cells including Sox2, KLF4, DMNT1 and MYC as well as TBGUT markers such as CD24, MUC1 and CD90. Furthermore, we indicate that the ATRA-induced expression of self-renewal genes and cancer stem cell markers of gastric cancer stem cells can be mediated by the regulation of the Notch signaling pathway.