Open AccessPreparation of Rutin Phytosome Complex
Author(s) -
Khanh T Nguyen
Publication year - 2018
Publication title -
tạp chí khoa học đại học quốc gia hà nội: khoa học y dược (vnu journal of science: medical and pharmaceutical sciences)
Language(s) - English
Resource type - Journals
eISSN - 2615-9309
pISSN - 2588-1132
DOI - 10.25073/2588-1132/vnumps.4123
Subject(s) - rutin , differential scanning calorimetry , bioavailability , chemistry , zeta potential , fourier transform infrared spectroscopy , nuclear chemistry , particle size , chromatography , antioxidant , organic chemistry , materials science , chemical engineering , pharmacology , nanotechnology , nanoparticle , medicine , physics , engineering , thermodynamics
Rutin is a flavonol glycoside, which has been reported to have antioxidant, anti-inflammatory, antithrombotic, antineoplastic, inhibit ultraviolet radiation-induced cutaneous oxidative stress and inflammation. The oral bioavailability of Rutin is very low. Phyto-phospholipid complex (phytosomes) is helpful in enhancing oral bioavailability and transdermal permeation of Rutin. Rutin phytosomes were prepared by using phosphatidylcholine (PC) and cholesterol by solvent evaporation and spray drying method. The physicochemical properties of phytosomes were evaluated using particle size analyses, polydispersity index, Zeta potential, encapsulation efficiency, furrier transformation infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and X-ray diffraction (XRD). Phytosomes with the rutin: PC: cholesterol molar ratios of 1:1:0.2 were prepared by spray drying showed the lowest particle size (266.4 nm), the highest encapsulation efficiency (95.61%). Results of the FT-IR, DSC and XRD studies confirmed the phyto-phospholipid complex formation.