Open AccessNghiên cứu bào chế viên nén Acid Nicotinic giải phóng kéo dài 24 giờ
Author(s) -
Phạm Thị Huế,
Bach Nguyen,
Sonekeo Phommasone
Publication year - 2017
Publication title -
tạp chí khoa học đại học quốc gia hà nội: khoa học y dược (vnu journal of science: medical and pharmaceutical sciences)
Language(s) - English
Resource type - Journals
eISSN - 2615-9309
pISSN - 2588-1132
DOI - 10.25073/2588-1132/vnumps.4059
Subject(s) - niacin , granulation , chemistry , dissolution , chromatography , matrix (chemical analysis) , nuclear chemistry , vitamin , dissolution testing , dosage form , biochemistry , organic chemistry , materials science , biopharmaceutics classification system , composite material
Niacin (nicotinic acid) is a highly water-soluble vitamin, which has been used asa lipid-lowering agent. Sustained release (SR) niacin tablet was developed in oder to maintain a constant drug concentration for a specific period of time with minimum side effects. In this study, the once daily extended release matrix tablets of niacin using a hydrophilic polymer of HPMC K100M as matrix excipientwere prepared by wet granulation method. The results of the dissolution study indicate that the release of the drug was found to be dependent on the proportions of HPMC used in the tablets. The dissolution profile of the optimal formula was similar to that of the predict and attained the requirements of USP 37. The dug incorporated in the matrix released by diffusionand fitted the first order kinetic.