Open AccessFrom nano to macro: Enabling Nanotechnologies for Human Organ Biofabrication (Electrospun Nanofibers and Hybrid Technique)
Author(s) -
Rodrigo Alvarenga Rezende,
Marcos A. Sabino,
Janaína Dernowsek,
Fábio de Albuquerque Vilalba,
Vladimir Mironov,
Jorge Vicente Lopes Silva
Publication year - 2018
Publication title -
international journal of advances in medical biotechnology
Language(s) - English
Resource type - Journals
ISSN - 2595-3931
DOI - 10.25061/2595-3931/ijamb/2018.v1i1.7
Subject(s) - biofabrication , nanotechnology , nanofiber , nanomaterials , materials science , nano , macro , computer science , tissue engineering , engineering , biomedical engineering , composite material , programming language
This review proposes to present how materials at nanolevel scale can contribute to the development of three-dimensional (3D) structures, human tissues, and organs which have macrolevel organization. Specific nanomaterials such as nanofibers and nanoparticles are presented and discussed in their application for biofabricating 3D human tissues and organs. The concept of self-assembling magnetic tissue spheroids as an intermediate mesolevel structure between nano and macrolevel organization and building blocks for biofabrication in dual scale level of complex 3D human tissues and organs is detached. The challenges and perspectives of employing nanomaterials and nanotechnological strategies in the biofabrication were also traced.