Transplante alogênico de medula óssea em crianças: experiência inicial do Hospital Santa Casa de Misericórdia de Belo Horizonte

OBJECTIVE: To report the clinical experience of a tertiary care hospital with allogeneic hematopoietic stem cell transplantation in children. METHODS: Data analysis of medical charts of the first 6 pediatric patients transplanted between April 2018 and December 2018. RESULTS: 6 patients (4 boys and 2 girls) with leukemia (5 ALL e 1 CML) received allogeneic transplants. The median age was 8 years. Donor sources were bone marrow (4 cases) and peripheral-blood stem cells (2 cases). All patients survived the first 100 days after transplantation and had a median clinical follow-up of 168 days. One patient developed acute GVHD and all patients developed at least one infection. Catheter-related bloodstream infections occurred in 66% of patients. Fever and mucositis were observed in all kids. The average length of stay at the hospital after transplantation was 38 days, 83% of the patients were admitted again due to infection or relapse. CONCLUSION: The obtained results are similar to others reported and make possible to know better all the factors that can influence the transplant success and survival in children and adolescents. However, Brazilian studies are still scarce. More studies should be encouraged, in order to increase the survive rate of our children.