Open AccessPleomorphic adenoma of the lacrimal gland: atypical location of a salivary tumor
Author(s) -
Araceli Gómez Rosso,
María Elena Samar,
Ávila Rodolfo,
Luis Ferraris,
Ismael Bernardo Fonseca,
Javier Elías Fernández
Publication year - 2020
Publication title -
revista de la facultad de odontología
Language(s) - English
Resource type - Journals
eISSN - 2545-7594
pISSN - 0325-1071
DOI - 10.25014/revfacodont271.2020.30.3.20
Subject(s) - pleomorphic adenoma , lacrimal gland , pathology , adenoma , medicine , immunostaining , immunohistochemistry , salivary gland , h&e stain , histopathology , benign tumor
In daily ophthalmological practice, lacrimal gland tumors are rare. They represent 5 to 7.5% of all intraorbital tumors. The most common epithelial tumor of this gland is the pleomorphic adenoma, with a percentage of 25 to 50% of its tumor lesions. Objective: In this communication we presented a case of lacrimal gland pleomorphic adenoma and study the expression of Ki67 and the location and expression of MUC-1 and its correlation with tumor prognosis. We also carried out a retrospective descriptive study of the literature on the subject published between 1951 and 2020, using the MEDLINE database. Material and methods: The surgical piece examined, was processed according to the paraffin embedding technique, was performed with a histopathological diagnosis of pleomorphic lacrimal gland adenoma. Histological sections were stained with Hematoxylin / Eosin. Immunostaining with Ki67 and MUC-1 was performed with the DAKO LSAB + kit. Results: The diagnosis of hypercellular pleomorphic adenoma with areas of the remaining lacrimal gland was made. Ki67 labeling was low (≤15%). MUC-1 expression was intense, situated to the apical cell membrane of approximately 10% epitheliocytes from pseudoductal and cystic structures.Conclusions: Through histopathological evaluation, the correlation of Ki67 expression and the location and expression of MUC1, we verified that it is a non-recurrent pleomorphic adenoma without malignant transformation.