Open AccessEffects Of Minocycline Combined With Tinidazole For Treatment Of Chronic Periodontitis
Author(s) -
Jiangjian Huang,
Jianru Xue,
Jinchao Gu
Publication year - 2021
Publication title -
clinical and investigative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.391
H-Index - 47
eISSN - 1488-2353
pISSN - 0147-958X
DOI - 10.25011/cim.v44i3.36477
Subject(s) - tinidazole , minocycline , medicine , dental alveolus , periodontitis , visual analogue scale , adverse effect , gastroenterology , chronic periodontitis , gingival and periodontal pocket , dentistry , surgery , antibiotics , metronidazole , chemistry , biochemistry
Purpose: To investigate the therapeutic effects of minocycline combined with tinidazole in the treatment of chronic periodontitis (CP).Methods: Seventy-three CP patients treated May 2018–December 2019 at Yuyao People’s Hospital (Yuyao, China) were enrolled in this study: 34 were treated with minocycline alone (control group; CG) and 39 were treated with a combination of minocycline and tinidazole (observation group; OG). Both groups were treated continuously for four weeks and plaque index (PLI), bleeding index (BI), periodontal pocket depth (PD), periodontal attachment level (PAL) and alveolar bone height were compared before and after treatment. Pain was evaluated using the visual analogue scale (VAS). Levels of TNF-α and IL-6 before and after treatment were determined using an enzyme-linked immunosorbent assay. Adverse reactions were compared.Results: In each group, PLI, BI, PD, PAL and alveolar bone height were lower after treatment (P 0.05).Conclusion: Minocycline combined with tinidazole was more effective in treating CP than minocycline alone. This drug combination improved the periodontal indexes and inflammatory reaction of CP and relieved their pain. No significant difference in adverse reactions was seen.