Open AccessKIF4A: A potential biomarker for prediction and prognostic of prostate cancer
Author(s) -
Jiahong Chen,
Maozhang Li,
Shumin Fang,
Xiaobo Zhou,
Jinxian Liao,
ShengBang Yang,
Jianguo Zhu,
Renqiang He,
Jianming Lü,
Funeng Jiang,
Xiaoming Xu,
Weide Zhong
Publication year - 2020
Publication title -
clinical and investigative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.391
H-Index - 47
eISSN - 1488-2353
pISSN - 0147-958X
DOI - 10.25011/cim.v43i3.34393
Subject(s) - du145 , prostate cancer , lncap , oncology , medicine , cancer research , apoptosis , biochemical recurrence , cancer , prostatectomy , biology , biochemistry
Purpose: To investigate the clinical relevance and biological function of the kinesin super-family protein 4A (KIF4A) expression in prostate cancer (PCa).
Methods: We examined 1) the relationship between the expression of KIF4A and clinico-pathological characteristics of PCa patients using a tissue microarray and the Cancer Genome Atlas database, 2) the prognostic value of KIF4A expression in patients using Kaplan-Meier plots and 3) the functions of KIF4A in LNCaP and DU145 cells, such as cell proliferation, cell cycle and cell apoptosis.
Results: Compared with normal prostate, the mRNA and protein expressions of KIF4A were up-regulated in PCa. The up-regulation expression rates of KIF4A in PCa were significantly related to the Gleason score (P