Open AccessObstetrical and neonatal factors associated with optimal public banking of umbilical cord blood in the context of delayed cord clamping
Author(s) -
Anna Munro,
Daniel J. Corsi,
Lisa Martin,
Mike Halpenny,
Nicholas Dibdin,
Heidi Elmoazzen,
Mark Walker,
David S. Allan
Publication year - 2019
Publication title -
clinical and investigative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.391
H-Index - 47
eISSN - 1488-2353
pISSN - 0147-958X
DOI - 10.25011/cim.v42i3.33093
Subject(s) - umbilical cord , cord blood , medicine , context (archaeology) , cord , potency , blood volume , haematopoiesis , obstetrics , anesthesia , surgery , immunology , stem cell , biology , paleontology , in vitro , biochemistry , genetics
Purpose: To assess the association of specific newborn and maternal factors with indicators of increased blood-forming capacity in umbilical cord blood to
inform strategic collection strategies that could augment the quality of units in public cord blood banks.
Methods: Data regarding 268 consecutive cord blood units (CBUs) banked by Canadian Blood Services were analyzed. Multivariate analysis was performed to
identify factors associated with markers of hematopoietic potency and likelihood of utilization.
Results: Delayed clamping of the cord beyond 60 s was associated with reduced volume collected. Any delay in clamping of the cord was associated
with reduced total nucleated cell counts. Newborn weight >4,000 g was also associated with greater blood volume in the collection but not with other measures of hematopoietic potency. Cord blood acidosis at birth (pH