Prognostic significance of body mass index in breast cancer patients with hormone receptor-positive tumours after curative surgery | Zendy

Peng Xing | Zendy; LI Ji-guang | Zendy; Feng Jin | Zendy; Tingting Zhao | Zendy; Qun Liu | Zendy; Huiting Dong | Zendy; Xiao Wei | Zendy

Open Access

Prognostic significance of body mass index in breast cancer patients with hormone receptor-positive tumours after curative surgery

Author(s) -

Peng Xing,

LI Ji-guang,

Feng Jin,

Tingting Zhao,

Qun Liu,

Huiting Dong,

Xiao Wei

Publication year - 2013

Publication title -

clinical and investigative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.391

H-Index - 47

eISSN - 1488-2353

pISSN - 0147-958X

DOI - 10.25011/cim.v36i6.20627

Subject(s) - medicine , breast cancer , body mass index , underweight , oncology , overweight , univariate analysis , hormone receptor , stage (stratigraphy) , cancer , multivariate analysis , gynecology , gastroenterology , paleontology , biology

Purpose: Obesity has been recognized as a significant risk factor for postmenopausal breast cancer. The aim of this study is to investigate the prognostic significance of body mass index (BMI) in hormone receptor-positive, operable breast cancer.Methods: In this retrospective cohort study, 1,192 consecutive patients with curative resection of primary breast cancer were enrolled. Patients were assigned to two groups according to BMI: normal or underweight (BMI < 23.0 kg/m2) and overweight or obese (BMI ≥23.0 kg/m2). Associations among BMI and clinicopathological characteristics and prognosis of patients were assessed.Results: A high BMI was significantly (P < 0.01) correlated with age, nodal stage, ALNR, ER positivity, PR positivity and menopausal status at diagnosis. Univariate analysis revealed that BMI, pathologic T stage, nodal stage, axillary lymph node ratio (ALNR) and adjuvant radiotherapy history were significantly (P < 0.05) associated with disease-free survival and overall survival, irrespective of tumour hormone receptor status. Multivariate analysis revealed BMI as an independent prognostic factor in all cases and in hormone receptor-positive cases.Conclusion: A high BMI (≥23.0 kg/m^2) is independently associated with poor prognosis in hormone receptor-positive breast cancer.

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