Open AccessTreadmill Running Induces a Detrimental Metabolic Adaptation in the Diabetic Mouse
Author(s) -
Tom L. Broderick,
Jackie Sennott,
Joseph Morrissey,
Paul R. Standley
Publication year - 2007
Publication title -
clinical and investigative medicine
Language(s) - English
Resource type - Journals
eISSN - 1488-2353
pISSN - 0147-958X
DOI - 10.25011/cim.v30i3.1732
Subject(s) - glycemic , treadmill , medicine , endocrinology , diabetes mellitus , insulin , body weight , type 2 diabetes , turnover , insulin sensitivity , physical exercise , insulin resistance , management , economics
Background: Regular exercise is generally recommended for the treatment of type 2 diabetes. Exercise reduces body weight, increases insulin sensitivity, and improves glycemic control. The present study was designed to determine the impact of voluntary wheel and forced treadmill running on the metabolic state in the db/db mouse, a model of type 2 diabetes. Our hypothesis is that exercise training improves the metabolic status such that a reduction in body weight, blood glucose and insulin are observed, resulting in improved insulin sensitivity.
Methods: Male diabetic db/db mice were assigned to sedentary (DS), voluntary wheel running (DV), and treadmill running (DT) running groups for 12 weeks. Nondiabetic heterozygote littermates served as control (CN).
Results: After 12 weeks of training, DV and DT mice ran a total of 4.24 ± 0.18 km and 11.8 km, respectively. Data are expressed as mean ± SEM for 10-12 mice in each group. * P < 0.05 vs CN, † P < 0.05 vs DS
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Conclusions: Voluntary exercise training is beneficial in reducing body weight and blood glucose in the db/db mouse, but this effect is minor. Forced treadmill running, however, did not improve body weight, blood glucose and the hyperinsulinemic state remained. These results suggest that forced treadmill exercise training may actually worsen the metabolic state in this model of diabetes.