Open AccessEVALUATION OF ANTIHYPERLIPIDEMIC ACTIVITY OF ETHANOLIC EXTRACT OF CROSSANDRA INFUNDIBULIFORMIS LEAVES AND STEMS ON HIGH FAT DIET INDUCED HYPERLIPIDEMIA
Author(s) -
Galanki Vasantha,
Venkatesham Allenki,
Chitturi H. Dayakar
Publication year - 2020
Publication title -
international journal of pharmaceutical sciences and drug research
Language(s) - English
Resource type - Journals
ISSN - 0975-248X
DOI - 10.25004/ijpsdr.2020.120207
Subject(s) - hyperlipidemia , very low density lipoprotein , chemistry , cholesterol , sodium cholate , sucrose , methionine , corn oil , food science , lipid profile , peanut oil , endocrinology , biochemistry , lipoprotein , biology , diabetes mellitus , amino acid , raw material , organic chemistry
Hypercholesterolaemia is the state been depicted by an expanded greasy substances called lipids, rise in plasma TCs and TGs levels it is additionally called hyper lipoproteinemia. The present study was designed to investigate the hypolipidemic effect of ethanolic extract of Crossandra infundibuliformis leaves and stem (ECILS) in high fat diet (cholesterol 2%, sodium cholate 1%, sucrose 48%, peanut oil, methionine 4%, and 47% normal laboratory feed) . The rats feed with High-fat diet containing (cholesterol 2%, sodium cholate 1%, sucrose 48%, peanut oil, methionine 4%, and 47% normal standard laboratory feed) for 1 month, and then they are checked for the blood parameter levels like TC, TGs, LDL, VLDL, and HDL. Ethanolic extracts at low dose (100 mg/kg), significantly reduced the levels of TC, TGL, LDL, VLDL & increased the levels of HDL and reduced the body weights on 30st day, and at medium, high doses it reduced the levels of TC, TGL, LDL, VLDL & increased the levels of HDL and reduced the body weights.