Open AccessStudy on Bioactive Compounds of Jania rubens against Methicillin and Vancomycin Resistant Staphylococcus aureus
Author(s) -
Sasikala Chenniyappan,
Geetharamani Durairaj,
K Evetha
Publication year - 2019
Publication title -
international journal of pharmaceutical sciences and drug research
Language(s) - English
Resource type - Journals
ISSN - 0975-248X
DOI - 10.25004/ijpsdr.2019.110621
Subject(s) - antibacterial activity , staphylococcus aureus , antimicrobial , minimum inhibitory concentration , chemistry , bacteria , minimum bactericidal concentration , sponge , pathogenic bacteria , thin layer chromatography , traditional medicine , column chromatography , microbiology and biotechnology , biology , chromatography , medicine , botany , genetics
The study is planned to find the antimicrobial activity of the extract of Jania rubens and to isolate the bioactive compound against MRSA and VRSA. Jania rubens collected from Mandapam (Pudumadam) Coastal water, East coast of India and extracted with ethanol. Antibacterial activity of J. rubens was tested against gram positive, gram negative bacteria and drug resistant bacteria). The antibacterial activities were expressed as zone of inhibition, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) Identification of compounds from crude extract of J. rubens carried by column chromatography, thin layer chromatography and NMR analysis. Finally J. rubens could serve as useful source of new antibacterial agent.