Open AccessA Novel Approach of Artesunate Pellets for the Treatment of Malaria
Author(s) -
A R Shabaraya,
Ankit S Parulkar,
Krishnananda K Kamath,
D Shripathy
Publication year - 2018
Publication title -
international journal of pharmaceutical sciences and drug research
Language(s) - English
Resource type - Journals
ISSN - 0975-248X
DOI - 10.25004/ijpsdr.2018.100603
Subject(s) - artesunate , ethyl cellulose , pellets , malaria , drug , dosing , pharmacology , artemether , medicine , chemistry , artemisinin , materials science , plasmodium falciparum , immunology , organic chemistry , composite material , polymer
Tropical countries such as India are more prone to the malaria and around 2 million cases are reported annually. Malaria is one of the most prominent life threatening diseases in spite of many efforts made to fight against it. There are many clinically effective anti-malarial agents but the major reasons of malaria treatment failure are due to resistance development, incorrect dosing, poor drug quality, drug interactions, poor drug absorption and misdiagnosis. Current approach done in this study is to formulate a dosage form which can overcome these drawbacks. Here pellets of Artesunate were formulated by extrusion spheronization method using different concentration of ethyl cellulose and evaluated for preformulation studies, drug compatibility studies were carried out. Formulations were evaluated for particles size analysis, zeta potential and in-vitro dissolution studies. The pellets were obtained in the size range of 10 – 100μm. The evaluation results obtained showed that the formulation F4 having high concentration of ethyl cellulose showed the best release profile.