Open AccessDevelopment and Evaluation of Multilayered Layered Matrix Tablets of Water Soluble Drug
Author(s) -
Ravi Shekhar,
Pankaj Sharma
Publication year - 2018
Publication title -
international journal of pharmaceutical sciences and drug research
Language(s) - English
Resource type - Journals
ISSN - 0975-248X
DOI - 10.25004/ijpsdr.2018.100406
Subject(s) - drug delivery , guar gum , drug , matrix (chemical analysis) , zero order , granulation , controlled release , materials science , biomedical engineering , nanotechnology , chromatography , pharmacology , chemistry , mathematics , medicine , composite material , first order , biochemistry
A new approach to zero- order drug delivery that includes geometric factors is described. Systems such asmultilayered tablets and other geometrically altered devices have been created to perform this function. Themulti-layered matrix system overcomes inherent disadvantages of non-linearity associated with diffusioncontrolled matrix devices by providing additional release surface with time to compensate for the decreasingrelease rate. These formulations designed to deliver the drug at predetermined rate, maintain therapeuticallyeffective concentrations in systemic circulation for prolonged period of time. Recently, pharmaceutical researchhas focused on controlled drug delivery offer definite advantages over conventional release formulation of thesame drug. Controlled delivery systems that can provide zero-order drug delivery have the potential formaximizing efficacy while minimizing dose frequency and toxicity. In the present study, guar gum was used ashydrophilic matrix carrier for designing oral controlled drug delivery systems of highly soluble druglamivudine. Three layered matrix tablets of lamivudine prepared by wet granulation technique were subjectedfor various evaluating parameters and optimized.