Open AccessNovel Synthesis and Antimicrobial Activities of Thiazino-Oxazine Derivatives
Author(s) -
Dr.Pravina B. Piste
Publication year - 2018
Publication title -
international journal of pharmaceutical sciences and drug research
Language(s) - English
Resource type - Journals
ISSN - 0975-248X
DOI - 10.25004/ijpsdr.2018.100401
Subject(s) - triphosgene , thiazine , pharmacophore , antimicrobial , streptomycin , candida albicans , gram , chemistry , corpus albicans , antibacterial activity , combinatorial chemistry , organic chemistry , stereochemistry , microbiology and biotechnology , bacteria , biology , antibiotics , biochemistry , genetics , phosgene
In the designing and synthesis of new heterocyclic compounds, containing two different pharmacophores, we have carried out new series of 3-(4-chlorophenyl)-4-methylidene-4,8-dihydro-2H,5H-1,3-thiazino[5,4-e]-1,3-oxazine-2,5,7(3H)-trione derivatives (5a-5k) in good yields from the cyclization of 5-[(1E)-N- (4-chlorophenyl) ethanimidoyl] -4-hydroxy- 2H-1,3- thiazine-2,6(3H)-dione derivatives (4a-4k) with triphosgene. All the synthesized compounds (5a-5k) were confirmed by spectral analysis. The synthesized compounds (5a-5k) were screened in vitro for their antibacterial activities against S. subtilis (gram positive) and E. coli. (gram negative) while antifungal activity against C. albicans by cup plate method. Some of the products of series were found to have quite good activities as compared to the standard drug streptomycin and flucanozole.