Open AccessDesign, Synthesis and Chemical Hydrolysis Study of Codrugs of Metoprolol with Metformin
Author(s) -
Ganesh S. Andhale,
D. Giles,
Amit Kumar Das,
Basavraj Metikurki,
Gurubasavrajswamy Pm
Publication year - 2018
Publication title -
international journal of pharmaceutical sciences and drug research
Language(s) - English
Resource type - Journals
ISSN - 0975-248X
DOI - 10.25004/ijpsdr.2018.100207
Subject(s) - hydrolysis , succinic anhydride , maleic anhydride , chemistry , prodrug , metoprolol , fourier transform infrared spectroscopy , melting point , organic chemistry , nuclear chemistry , biochemistry , polymer , medicine , chemical engineering , cardiology , engineering , copolymer
In the present study we have synthesized ester prodrugs (Pa-i) of Metoprolol (I) by using pthalic anhydride and derivatives of succinic and maleic anhydride. Different codrugs (COa-i) were synthesized from prodrugs of metoprolol. All the codrugs were characterized by melting point, FTIR, NMR and Mass Spectroscopy. The chemical hydrolysis of COa-i were investigated at the pH 1.2, 6.8 and 7.4. Presence of maleate, methyl maleate, dimethyl maleate and succinate group as linker were found to possess good hydrolysis when compared to that of other substitutes. Among the synthesized codrugs, COf is found to be the best one among the series