Open AccessFormulation and Evaluation of Mouth Dissolving Tablets of Ondansetron Hydrochloride Using Plantago ovata (Isapghula) Mucilage as Natural Super Disintegrating Agent
Author(s) -
RezaSunidhi Mahant,
Shivali Singla,
Sachin Goyal,
Bhimi Kumari,
Abhishek Soni
Publication year - 2017
Publication title -
international journal of pharmaceutical sciences and drug research
Language(s) - English
Resource type - Journals
ISSN - 0975-248X
DOI - 10.25004/ijpsdr.2017.090507
Subject(s) - mucilage , friability , dissolution , plantago ovata , chromatography , chemistry , dosage form , pharmacology , ondansetron , bioavailability , materials science , medicine , first pass effect , nausea , botany , organic chemistry , anesthesia , biology
Mouth dissolving tablet is an innovative solid unit dosage form that overcome the problem of swallowing and provide rapid disintegration and dissolution to release the drug as soon as they come in contact with saliva, hence provide quick onset action. The aim of this study was to formulate and evaluate mouth dissolving tablets of Ondansetron hydrochloride using natural super disintegrating agent. Ondansetron hydrochloride is a serotonin receptor (5-HT3) antagonist used to treat nausea and vomiting arises during chemotherapy and radiation therapy. Mouth dissolving tablets were prepared by direct compression method using natural super disintegrating agent (Plantago ovata mucilage). Prepared tablet were evaluated for Hardness, weight variation, friability, thickness, wetting time, dispersion time, water absorption ratio, disintegration and dissolution study. According to results of optimized batches it has been concluded that Formulation batch F6 was an ideal batch which contain 12% w/v concentration of Plantago ovata mucilage showed least disintegration time that is 7 seconds and maximum drug release of (98.57%) within 15 minutes and was best among all the formulations.