Open AccessFormulation and Evaluation of Mouth Dissolving Tablets Containing Losartan Potassium Using Natural Superdisinigrants
Author(s) -
Bhimi Kumari,
Abhishek Soni,
Shivali Singla,
Sachin Goyal,
Samriti Thakur,
Sunidhi Mahant
Publication year - 2017
Publication title -
international journal of pharmaceutical sciences and drug research
Language(s) - English
Resource type - Journals
ISSN - 0975-248X
DOI - 10.25004/ijpsdr.2017.090506
Subject(s) - friability , dissolution , bioavailability , losartan potassium , onset of action , chromatography , potassium , pharmacology , chemistry , materials science , first pass effect , losartan , medicine , metallurgy , organic chemistry , biochemistry , angiotensin ii , receptor
Losartan potassium is used as an antihypertensive drug but it goes under first pass metabolism due do which it has low bioavailability. Fast onset of action is major concern in the management of hypertension. Therefore the aim of this study is to formulate mouth dissolving tablet of losartan potassium to improve its bioavailability, to achieve fast onset of action and increase patient compliance. Mouth dissolving tablets were prepared by direct compression method using natural super disintegrating agents (banana powder and apple pectin) and evaluated for pre-compression parameters and post compression parameters such as appearance, dimensions, hardness, weight variation, friability, wetting time, dispersion time, water absorption ratio, disintegration and dissolution study. According to results of optimized batches it has been concluded that formulation batch F9 was an ideal batch which contain banana powder (2.5%) and cross povidone (2.5%) showed least disintegration time that is 26 seconds and maximum drug release of (99.68%) within 12 minutes and was best among all the formulations.