Open AccessA Novel Technique to Enhance Dissolution Rate of Cilnidipine Using Liquisolid Compact and Wet Granulation
Author(s) -
Vinod Valjibhai Siju,
Moinuddin Soniwala,
Swati Nagar
Publication year - 2017
Publication title -
international journal of pharmaceutical sciences and drug research
Language(s) - English
Resource type - Journals
ISSN - 0975-248X
DOI - 10.25004/ijpsdr.2017.090402
Subject(s) - dissolution , granulation , solubility , sodium hydroxide , drug , water soluble , dissolution testing , meglumine , chromatography , chemistry , materials science , nuclear chemistry , pharmacology , chemical engineering , organic chemistry , composite material , medicine , biopharmaceutics classification system , magnetic resonance imaging , radiology , engineering
The main objective of the work was to improve the dissolution rate of the drug, Cilnidipine (CLD) by using the liquisolid compact technique and wet granulation. Cilnidipine drug is poorly soluble in water and it’s highly soluble in higher pH. In this study drug is solubilize in tween 80 and sodium hydroxide and meglumine solution. And then drug solution binding on Pearlitol SD 200. PVP K30 used as a binder and crospovidone used as a disintegrant. Sodium hydroxide and meglumine used as a buffering agent for basic media preparation. The drug release rates of tablets which prepared by liquisolid compact have higher solubility and dissolution than conventional tablets.