Open AccessEvaluation of in vitro Antiviral Activity of Hypericum mysorense F. Heyne against HSV-2
Author(s) -
Sundaramoorthy Marimuthu,
Sheik Noor Mohamed M,
P Saravanan,
D Anand,
S Rajarajan
Publication year - 2017
Publication title -
international journal of pharmaceutical sciences and drug research
Language(s) - English
Resource type - Journals
ISSN - 0975-248X
DOI - 10.25004/ijpsdr.2017.090106
Subject(s) - herpes simplex virus , hypericum , traditional medicine , medicinal plants , in vitro , virus , mtt assay , biology , cell culture , virology , microbiology and biotechnology , pharmacology , chemistry , medicine , biochemistry , genetics
The medicinal plants have played a vital role in drug discovery. Many plants are used traditionally for the treatment of different types of viral disorders and other infectious diseases. Herpes simplex virus (HSV) is a ubiquitous organism that causes infections in human populations throughout the world. It causes a variety of diseases ranging in severity from mild to life-threatening. The present study was to evaluate antiviral activity of Hypericum mysorense F. Heyne ethanolic leaf extract against herpes simplex virus type 2 (HSV-2) using HEp-2 cell line. The toxic free concentrations of ethanolic extract were determined using MTT assay, followed by anti HSV-2 activity and a positive control was maintained. 50?g/ml of ethanol extract was observed to be maximum non toxic free concentration against HEp-2 cell line and also exhibited significant inhibitory activity against HSV-2.