Open AccessAntioxidant Activities of Inclusion Complexes of 2-(Benzothiazolyl-2�) Hydrazono-3-Phenyl 5-Arylidene- 4- Thiazolidinone Derivatives with ?-Cyclodextrin
Author(s) -
Mahendar Rupavath,
Baijayantimala Garnaik
Publication year - 2017
Publication title -
international journal of pharmaceutical sciences and drug research
Language(s) - English
Resource type - Journals
ISSN - 0975-248X
DOI - 10.25004/ijpsdr.2017.090103
Subject(s) - antioxidant , chemistry , cyclodextrin , inclusion (mineral) , solubility , organic chemistry , combinatorial chemistry , mineralogy
The present study focused on the preparation and antioxidant studies of inclusion complexes of some compounds of 4-Thiazolidinone derivatives with ?-cyclodextrin. The inclusion complex has been prepared in order to increase solubility and bio-accessibility of the parent compound. The experiment was conducted by taking 2-Hydrazinobenzothiazole as a starting material and a series of compounds and their inclusion is prepared from it. Taking into account on their physical, thermal and spectral characteristics (UV, IR and NMR), the formation of compounds and their inclusion complex are confirmed. From the antioxidant activities of compounds and inclusion complex, it has been found that inclusion complex has displayed more effectively than the original compounds.