Open AccessAnti-Urolithiatic Potential of Methanolic Extract of Hygrophila salicifolia on Ethylene Glycol Induced Urolithiasis in Rats
Author(s) -
Mehul K. Bhatt,
Nehal Shah
Publication year - 2016
Publication title -
international journal of pharmaceutical sciences and drug research
Language(s) - English
Resource type - Journals
ISSN - 0975-248X
DOI - 10.25004/ijpsdr.2016.080602
Subject(s) - ethylene glycol , chemistry , traditional medicine , creatinine , urine , calcium oxalate , oxalate , chromatography , medicine , biochemistry , organic chemistry
The anti-urolithiatic action of Hygrophila salicifolia (Acanthaceae) was determined by ethylene glycol induced lithiasis. Ethylene glycolated water (0.75% v/v) was given to experimental animals for 28 days to produce stone in kidney. Methanolic extracts of Hygrophila salicifolia were given from the 1st day as inhibitory agent. Urinary parameters such as calcium, oxalate and inorganic phosphate level were raised by ethylene glycol where as test extract lowered down the raised level of these ions in urine. Methanolic extract of Hygrophila salicifolia also increased urinary magnesium concentration while raised concentration of serum creatinine was found to be cut down during the experiment. Methanolic extract of test drug was found impressively better from histological study. These results obtained from the study confirmed the anti-urolithiatic potential of Hygrophila salicifolia