Open AccessFormulation and Evaluation of Matrix Type Transdermal Patches of Glibenclamide
Author(s) -
J. R. D. Gupta,
Raghuveer Irchhiaya,
Navneet Garud,
Priyanka Tripathi,
Prashant Dubey,
Jinal Patel
Publication year - 2009
Publication title -
international journal of pharmaceutical sciences and drug research
Language(s) - English
Resource type - Journals
ISSN - 0975-248X
DOI - 10.25004/ijpsdr.2009.010111
Subject(s) - folding endurance , transdermal , plasticizer , permeation , glibenclamide , polyethylene glycol , penetration (warfare) , solvent , chromatography , chemistry , dimethyl sulfoxide , peg 400 , peg ratio , polymer , aluminium foil , materials science , pharmacology , organic chemistry , membrane , biochemistry , medicine , finance , operations research , ethyl cellulose , economics , diabetes mellitus , endocrinology , layer (electronics) , engineering
Matrix type transdermal patches containing Glibenclamide were prepared using three different polymers by solvent evaporation technique. Aluminium foil cup method was used as a substrate. Polyethylene glycol (PEG) 400 was used as plasticizer and Dimethyl sulfoxide (DMSO) was used as penetration enhancer. The physicochemical parameters like weight variation, thickness, folding endurance, drug content, % moisture absorption and % moisture loss were evaluated. In vitro drug release studies and skin permeation studies were carried out using Franz diffusion cell. Cumulative amount of drug released in 12 hours from the six formulations were 55.467, 52.633, 47.157, 53.394, 49.139 and 45.597 %, respectively. The corresponding values for cumulative amount of drug permeated for the said formulation were 43.013, 40.429, 37.793, 41.522, 37.450 and 34.656 %, respectively. On the basis of in vitro drug release and skin permeation performance, formulation HP-1 was found to be better than other formulations and it was selected as the optimized formulation.