Open AccessEffects of Duration and Complications of Type 2 Diabetes Mellitus on Diabetic Related Parameters, Adipocytokines and Calcium Regulating Hormones
Author(s) -
Aseel Khalid Thabah Al-Attaby,
Makarim Q. Al-Lami
Publication year - 2019
Publication title -
iraqi journal of science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.152
H-Index - 4
eISSN - 2312-1637
pISSN - 0067-2904
DOI - 10.24996/ijs.2019.60.11.5
Subject(s) - medicine , adipokine , endocrinology , diabetes mellitus , glycated hemoglobin , adiponectin , resistin , vitamin d and neurology , hormone , parathyroid hormone , type 2 diabetes mellitus , insulin , insulin resistance , calcitonin , type 2 diabetes , calcium
The present study aims to investigate the effects of duration and complications of type 2 diabetes mellitus on diabetic related parameters, adipocytokines and calcium regulating hormones. This study was conducted on eighty diabetic patients (41 male and 39 female) in Iraq, with an age range of 20-60 years and a disease duration range of 1-180 months. Blood samples were collected from the patients to determine three main types of biomarkers: diabetic-related parameters [Fasting blood sugar is FBS glycated hemoglobin (HbA1c), insulin, and insulin resistance (IR)], adipocytokines [adiponectin and tumor necrosis factor-α (TNF-α), and calcium regulating hormones [parathyroid hormone (PTH), calcitonin, and vitamin D].
The result showed increased levels of some parameters with the increase in duration of disease. Levels of FBS and HbA1c increased significantly (probability 0.05) differences were found in the levels of adiponectin and PTH among all categories of duration of disease.
When a comparison was made between the two groups of patients (with complications and without complications), a significant (P 0.05) differences were found in the levels of the other parameters (adiponectin, TNF-α, PTH and vitamin D) between the two groups of patients.
It can be concluded from the present study that duration of disease affects diabetic related parameters, TNF-α and some calcium regulating hormones (calcitonin and vitamin D), while complications of disease affect diabetic related parameters and calcitonin. It can be suggested that the duration of diabetes is one of the strongest determinants of complication risk.